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Updated: Jun 25, 2026

Synthesis of Metal Nanoparticles Supported on Carbon Nanotube with Doped Co and N Atoms and its Catalytic Applications in Hydrogen Production
Published on: December 6, 2021
Cobalt-catalyzed N-arylation of nitrogen nucleophiles in water
Yong-Chua Teo1, Guan-Leong Chua
1Natural Sciences and Science Education, National Institute of Education, Nanyang Technological University, 1 Nanyang Walk, Singapore. yongchua.teo@nie.edu.sg
Abstract:
Cobalt 'n' cross-coupling! A facile and practical strategy catalyzed by CoCl(2)6 H(2)O has been developed for the N-arylation of nitrogen nucleophiles with substituted aryl halides in water. The protocol is very simple and requires only mild conditions. A variety of nitrogen nucleophiles, including pyrazole, indole, and 7-azaindole, undergo catalysis to afford N-arylated products in moderate to good yields (up to 86 %; see scheme).
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