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Updated: Jun 25, 2026
10:44
One-step Negative Chromatographic Purification of Helicobacter pylori Neutrophil-activating Protein Overexpressed in Escherichia coli in Batch Mode
Published on: June 18, 2016
Helicobacter pylori, asthma and allergy
Mario Milco D'Elios1, Gaia Codolo, Amedeo Amedei
1Department of Internal Medicine, University of Florence, Florence, Italy. delios@unifi.it
FEMS Immunology and Medical Microbiology
|February 18, 2009
Summary
Helicobacter pylori
Area of Science:
- Immunology
- Microbiology
- Allergy Research
Background:
- Allergic diseases and bronchial asthma are driven by T-helper type 2 (Th2) cytokines.
- Th1 immune responses, characterized by interferon-gamma and IL-12, can inhibit Th2 activity.
- Helicobacter pylori infection elicits a Th1 response.
Purpose of the Study:
- To investigate the role of H. pylori neutrophil-activating protein (HP-NAP) in modulating Th1/Th2 immune responses.
- To evaluate HP-NAP's potential for preventing and treating allergic diseases.
Main Methods:
- In vitro and in vivo studies using allergic bronchial asthma models in humans and mice.
- Administration of HP-NAP via systemic and mucosal routes.
- Assessment of Th2 cytokine levels, immunoglobulin E, and eosinophilia.
Main Results:
- HP-NAP drives Th1 inflammation and inhibits Th2 responses.
- HP-NAP administration reduced eosinophilia, immunoglobulin E, and Th2 cytokines in bronchial asthma.
- Both systemic and mucosal HP-NAP treatments were effective.
Conclusions:
- HP-NAP demonstrates potential as a therapeutic agent for allergic diseases.
- HP-NAP may offer novel strategies for the prevention and treatment of conditions like bronchial asthma.
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