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Published on: December 17, 2021
Bilateral uveitis secondary to bisphosphonate therapy
Yar Li Tan1, Joanne Sims, Soon Phaik Chee
1Singapore National Eye Centre, Singapore, Singapore.
Summary
Bisphosphonate therapy can cause bilateral uveitis, a serious ocular side effect. Discontinuing the drug and seeking ophthalmologist care can resolve inflammation and prevent recurrence.
Area of Science:
- Ophthalmology
- Pharmacology
Background:
- Bisphosphonates are commonly prescribed for osteoporosis and other bone diseases.
- Nitrogen-containing bisphosphonates have been associated with various ocular side effects.
Observation:
- Two cases of bilateral anterior uveitis developed in patients receiving nitrogen-containing bisphosphonates.
- Uveitis screening tests were normal in both affected individuals.
Findings:
- Ocular inflammation resolved completely after the discontinuation of bisphosphonate therapy.
- No recurrence of uveitis was observed during follow-up periods of 5 and 6 months.
Implications:
- Prompt ophthalmological referral is crucial for patients on bisphosphonates presenting with ocular symptoms.
- Discontinuation of the offending bisphosphonate is essential to prevent chronic or recurrent ocular inflammation.
- Switching to non-nitrogen-containing bisphosphonates may be considered for susceptible patients.
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