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Conduction block in diabetic neuropathy.

S R Abu-Shakra1, D R Cornblath, O L Avila

  • 1Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205.

Muscle & Nerve
|September 1, 1991
PubMed
Summary
This summary is machine-generated.

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Conduction block is uncommon in diabetic neuropathy, affecting only a small number of patients. If present, it may indicate other underlying causes for the nerve damage in diabetics.

Area of Science:

  • Neurology
  • Diabetology
  • Electrophysiology

Background:

  • Diabetic polyneuropathy commonly affects sensory and motor nerves, leading to reduced nerve function.
  • Pathologic studies indicate both demyelination and axon loss in diabetic neuropathy.
  • Conduction block, a sign of segmental demyelination, has not been previously investigated in diabetic neuropathy.

Purpose of the Study:

  • To determine the prevalence of conduction block in patients with diabetes.
  • To analyze electrodiagnostic data for evidence of conduction block in diabetic neuropathy.

Main Methods:

  • Analyzed electrodiagnostic data from 24 diabetic patients.
  • Defined conduction block by a >20% drop in peak-to-peak amplitude and <15% change in negative-peak duration between proximal and distal stimulation.

Related Experiment Videos

  • Examined 76 nerve segments for criteria of conduction block.

    • Main Results:

    • Conduction block was identified in only 6 segments across 6 patients.
    • The mean amplitude decrease in affected segments was 28% (range 21%–40%).

    Conclusions:

    • Conduction block over long nerve segments is infrequent in diabetic neuropathy.
    • The presence of conduction block may suggest alternative etiologies for neuropathy in diabetic individuals.