[Distribution and antibiotic resistance of pathogens isolated from children with infectious diarrhea in Guangzhou]

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A High-throughput Platform for the Screening of Salmonella spp./Shigella spp.
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Published on: November 7, 2018

Yong-Qiang Xie1, Qiu-Lian Deng, Yan Guo

  • 1Guangzhou Children's HospitalìGuangzhou 510120, China.

Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics
|February 19, 2009
PubMed

Insights

Shigella, enteropathogenic Escherichia coli, and Salmonella are key causes of infectious diarrhea in Guangzhou children. These pathogens remain susceptible to imipenem and third-generation cephalosporins, but show high resistance to ampicillin.

Area of Science:

  • Pediatric infectious diseases
  • Microbiology
  • Antimicrobial resistance

Context:

  • Infectious diarrhea is a significant health concern in pediatric populations.
  • Understanding the etiological agents and their resistance patterns is crucial for effective treatment.
  • Guangzhou, China, presents a specific epidemiological context for pediatric infectious diarrhea.

Purpose:

  • To determine the prevalence and antibiotic susceptibility profiles of bacterial pathogens causing infectious diarrhea in children in Guangzhou.
  • To identify the primary causative agents of infectious diarrhea in this demographic.
  • To assess resistance trends against commonly used antibiotics.

Summary:

  • A study of 2,409 children with infectious diarrhea in Guangzhou identified 448 pathogenic bacterial isolates.
  • Shigella, enteropathogenic E. coli, and Salmonella were the predominant pathogens.
  • While susceptible to imipenem and third-generation cephalosporins, isolates exhibited high resistance to ampicillin and sulfamethoxazole/trimethoprim.

Impact:

  • Provides essential data for guiding empirical antibiotic therapy for pediatric infectious diarrhea in Guangzhou.
  • Highlights the need for antimicrobial stewardship to combat rising resistance to certain drugs.
  • Informs public health strategies for controlling infectious diarrhea outbreaks in children.
Abstract

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