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Updated: Jun 25, 2026

Measurements of Physiological Stress Responses in C. Elegans
Published on: May 21, 2020
Cell stress and aging: new emphasis on multiplex resistance mechanisms
1Department of Pathology and Geriatrics Center, University of Michigan, 109 Zina Pitcher Place, Ann Arbor, MI 48109-2200, USA. millerr@umich.edu
Abstract:
Work, initially in Caenorhabditis elegans and then more recently in fruit flies and mice, has suggested that anti-aging mutations extend life span by simultaneous activation of pathways that protect cells from multiple forms of injury. This "multiplex stress resistance" theory suggests a number of new avenues for investigation of the genetic and cellular controls that influence organismic longevity within and among species, and that might lead to the development of pharmaceuticals that retard the aging process and, therefore, the entire panoply of age-dependent diseases and disabilities.
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