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The type VI secretion system: a tubular story
1Division of Cell and Molecular Biology, Imperial College London, Centre for Molecular Microbiology and Infection, London, UK. a.filloux@imperial.ac.uk
The EMBO Journal
|February 20, 2009
Summary
Gram-negative bacteria use type VI secretion systems (T6SS) to secrete proteins. New research reveals a novel tubular structure interacting with ClpV ATPase, challenging current models of T6SS function.
Area of Science:
- Microbiology
- Molecular Biology
- Bacterial Pathogenesis
Background:
- Gram-negative bacteria utilize sophisticated secretion systems, including the type VI secretion system (T6SS), for protein transport.
- The ClpV ATPase was previously implicated in energizing the secretion of key T6SS effectors like Hcp and VgrG proteins.
Discussion:
- This study identifies a previously unknown tubular structure associated with the T6SS.
- This structure interacts with the ClpV ATPase, suggesting a more complex mechanism than previously understood.
- The findings necessitate a revision of the current working model for T6SS protein secretion.
Key Insights:
- Discovery of a novel tubular structure involved in T6SS function.
- Demonstration of the tubular structure's interaction with ClpV ATPase.
- Implication of this interaction in the energy transduction for protein transport.
Outlook:
- Further investigation into the precise role and composition of the novel tubular structure.
- Elucidation of how this structure integrates with the known T6SS components.
- Potential for new therapeutic targets by understanding T6SS regulation and function.
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