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Characterizing Mammalian Zinc Transporters Using an In Vitro Zinc Transport Assay
Published on: June 2, 2023
A ratiometric fluorescent sensor with a large Stokes shift for imaging zinc ions in living cells
1Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Photochemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.
Chemical Communications (Cambridge, England)
|February 20, 2009
Abstract:
The ratiometric fluorescent sensor based on furoquinoline has been designed and synthesized, and not only exhibits a large Stokes shift of 199 nm in a mixture of C(2)H(5)OH-H(2)O (v/v = 8 ratio 2, 10 mM Tris-HCl, pH = 7.3), but can selectively detect zinc ions in the presence of competing metal ions with a red-shift of 75 nm; moreover, cell stain experiments show that can readily reveal a change in intracellular Zn(2+).