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Updated: Jun 25, 2026

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
Published on: March 3, 2023
Disturbed cognitive functions after nasal provocation in patients with seasonal allergic rhinitis
I Hartgerink-Lutgens1, A Vermeeren, E Vuurman
1Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Health, Medicine and Life Sciences, University Hospital Maastricht, Maastricht University, Maastricht, The Netherlands. isabelle.hartgerink@mumc.nl
Background:
Allergic rhinitis (AR) reduces quality of life as a result of impaired psychological well-being and perceived impaired cognitive functioning. Few studies have measured cognitive functions objectively and it remains uncertain whether AR leads to an objective reduction in cognitive functions.
Objective:
The present study investigated whether AR is associated with a decrement in several aspects of cognitive functioning. Furthermore, the study investigated whether AR patients invest more 'mental effort' in order to achieve the same cognitive performances as healthy controls.
Methods:
Twenty five patients with seasonal allergic rhinitis (SAR) and 26 healthy controls, matched for age, education and sex, were tested on a battery of time-demanding and strenuous objective cognitive tests and subjective questionnaires, both before and after nasal provocation (NP). The cognitive functions assessed were sustained attention, short- and long-term memory and speed of information processing. Mental effort was assessed using visual rating scales.
Results:
Sustained but not short cognitive performance was impaired in patients after NP. Patients showed an increased effort on short cognitive tests.
Conclusion:
SAR patients suffer from cognitive performance decrements that can be compensated by additional mental effort for short tasks only.
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