[Lung pathology in HIV-associated infections]
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Updated: Jun 25, 2026

Processing of Bronchoalveolar Lavage Fluid and Matched Blood for Alveolar Macrophage and CD4+ T-cell Immunophenotyping and HIV Reservoir Assessment
Published on: June 23, 2019
Abstract:
The lung and intrathoracic lymph nodes taken from 153 persons who had taken from HIV infection at the age of 20 to 32 years, with the development of various infectious diseases were examined. Secondary diseases were of generalized progressive pattern. Among these diseases accompanied by pulmonary lesions tuberculosis, as well as bacterial pneumonias, cytomegalovirus infection, pneumocystic pneumonia, cryptococcosis, and non-tuberculous mycobacterial diseases were most common. Lung tissue reactions at terminal stages of HIV infection were polymorphic, which had been caused by severe immunodeficiency, a change in the course of diseases, obliteration of typical morphological signs, and a mixed lung lesion. This makes the differential diagnosis of diseases difficult and requires a comprehensive study of specimens in each specific case, by widely employing additional methods and stains to detect different pathogens.
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