[Clinical relevance of chromosome analyses in couples with repeated miscarriage]

To investigate the efficiency of offering parental karyotyping in couples with repeated miscarriage.

For a period of 5 years cytogenetic study have been performed in 478 couples (956 patients) with at least two spontaneous first trimester abortions or one spontaneous first trimester abortion and one late fetal death.

Chromosome abnormalities were found in 14 (2.9%) patients. The chromosomal abnormalities were structural 13 (2.72%) and numerical 1 (0.20%). Polymorphisms of heterochromatin blocks and inv (9) were shown in 29 (6.06%) patients. The children born after prenatal diagnosis were with normal phenotype. Two of them were carriers as their parents.

Chromosome analyses are an important and necessary part of the etiological research in couples with recurrent fetal wastage. Thus unbalanced offspring will not be permitted.