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Bioreactor Controls-I01:28

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Maintaining optimal conditions within fermenters is essential for maximizing microbial productivity and ensuring process efficiency. This lesson focuses on key parameters—temperature, foam, pH, carbon dioxide, oxygen, and pressure—and their precise measurement and control strategies in fermentation systems.Temperature ControlTemperature regulation is critical due to the exothermic nature of many fermentation processes. In small laboratory fermenters, temperature is commonly monitored using...

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Protocol for Relative Hydrodynamic Assessment of Tri-leaflet Polymer Valves
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Published on: October 17, 2013

New technology: valve repair using biodegradable rings.

Rodolfo Neirotti1, Mustafa Cikirikcioglu, Alberto Della Martina

  • 1University Hospital of Geneva, 24 rue Micheli du Crest, Geneva, Switzerland. RA_Neirotti@ksg06.harvard.edu

Revista Brasileira De Cirurgia Cardiovascular : Orgao Oficial Da Sociedade Brasileira De Cirurgia Cardiovascular
|February 21, 2009
PubMed
Summary
This summary is machine-generated.

New biodegradable annuloplasty rings offer improved cardiac valve repair for adults and children. These rings support valve function, allow for growth in pediatric patients, and show promising mid-term results without adverse effects.

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Area of Science:

  • Cardiovascular Surgery
  • Biomaterials Science
  • Medical Device Technology

Background:

  • Current annuloplasty rings (rigid and flexible) have limitations in accommodating dynamic cardiac changes and pediatric growth.
  • The need for advanced annuloplasty devices that preserve native valve geometry and allow for physiological remodeling is critical.

Purpose of the Study:

  • To introduce and evaluate a novel polidioxanone biodegradable annuloplasty ring (Bioring) for mitral and tricuspid valve repair.
  • To assess the safety, efficacy, and growth potential of biodegradable rings in both adult and pediatric patient populations.

Main Methods:

  • A prospective study involving 207 patients (121 adults, 86 pediatric) undergoing mitral and/or tricuspid valve repair with Bioring implantation from March 2003 to March 2007.
  • Patients were stratified into adult and pediatric groups with detailed demographic data and follow-up protocols.

Main Results:

  • Adult group (n=121): 3.3% hospital mortality; mean follow-up 26.4 months; 4 patients required mitral valve replacement post-repair.
  • Pediatric group (n=86): 1.2% hospital mortality; mean follow-up 26.7 months; 7 patients required mitral reoperations (2 re-repairs, 5 replacements).

Conclusions:

  • Biodegradable annuloplasty rings effectively remodel, reinforce, and restore atrioventricular valve function while maintaining dynamic annular geometry.
  • The Bioring preserves growth potential in pediatric patients and shows no observable negative consequences during mid-term follow-up.
  • This technology offers a viable option for adult and pediatric valve repair, including complex cases like single ventricle with AV valve incompetence.