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Ascending Aortic Aneurysms: From Pathophysiology to Surgical Repair
Waël Oweini1, Jalal Jolou2, Tornike Sologashvili2
1Faculty of Medicine, University of Geneva, 1206 Geneva, Switzerland.
Journal of Clinical Medicine
|October 16, 2025
Summary
Ascending aortic aneurysms are active organs, not passive. New strategies integrate genetics, imaging, and hemodynamics for personalized risk assessment beyond diameter alone.
Area of Science:
- Cardiovascular Research
- Vascular Biology
- Medical Imaging
Background:
- The aorta is an active organ regulating hemodynamics and homeostasis.
- Ascending aortic aneurysms (AAAs) often present silently, leading to dissection or rupture.
- Current diameter-based surgical thresholds are insufficient, missing many dissections.
Purpose of the Study:
- To review recent advances in understanding ascending aortic aneurysms.
- To explore novel diagnostic markers and evolving surgical strategies.
- To highlight the shift towards personalized risk assessment.
Main Methods:
- Narrative review of current literature.
- Analysis of genetic and degenerative mechanisms.
- Evaluation of morphological, hemodynamic, and imaging markers.
Main Results:
- AAAs involve complex genetic and degenerative pathways.
- Novel markers offer improved risk stratification beyond diameter.
- Advanced imaging enhances diagnostic capabilities.
Conclusions:
- Integrating biological, morphological, and clinical data is key.
- Personalized risk assessment can optimize surgical timing.
- Improved detection and management enhance patient outcomes.
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