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One-pot approach to well-defined biomolecular assemblies by orthogonal chemoselective ligations

Mathieu Galibert1, Pascal Dumy, Didier Boturyn

  • 1Départment de Chimie Moléculaire, UMR CNRS/UJF 5250, ICMG FR 2607, 301, rue de la chimie, BP53, 38041 Grenoble cedex 9, France.

Angewandte Chemie (International Ed. in English)
|February 21, 2009
PubMed

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Ligand Binding Sites

Proteins are dynamic macromolecules that carry out a wide variety of essential processes; however, the activities of most proteins depend on their interactions with other molecules or ions, known as ligands.
Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...