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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

Gold-catalyzed [4C+3C] intramolecular cycloaddition of allenedienes: synthetic potential and mechanistic implications

Beatriz Trillo1, Fernando López, Sergi Montserrat

  • 1Departamento de Química Orgánica, Universidad de Santiago de Compostela, Facultad de Química, 15782, Santiago de Compostela, Spain.

Chemistry (Weinheim an Der Bergstrasse, Germany)
|February 21, 2009
PubMed

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Cycloaddition Reactions: Overview

Cycloadditions are one of the most valuable and effective synthesis routes to form cyclic compounds. These are concerted pericyclic reactions between two unsaturated compounds resulting in a cyclic product with two new σ bonds formed at the expense of π bonds. The [4 + 2] cycloaddition, known as the Diels–Alder reaction, is the most common. The other example is a [2 + 2] cycloaddition.
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Cyclohexenones via Michael Addition and Aldol Condensation: The Robinson Annulation

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Cycloaddition Reactions: MO Requirements for Photochemical Activation

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