Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Structure of Blood Vessels

Structure of Blood Vessels

Blood is circulated throughout the human body through a network of blood vessels called the circulatory system. This system includes arteries that transport blood from the heart to various body parts. These arterial pathways divide into smaller vessels until they reach the arterioles, which further split into capillaries. It is within these minuscule capillaries that the exchange of nutrients and waste products takes place. After this exchange, the blood is collected by venules, which fuse to...

Eccentric Axial Loading in a Plane of Symmetry

Eccentric Axial Loading in a Plane of Symmetry

Eccentric axial loading occurs when an axial load is applied away from the centroidal axis of a structural member. This scenario is common in engineering, where structural elements may not be directly aligned due to various design or functional requirements.

Relation between Poisson's ratio, Modulus of Elasticity and Modulus of Rigidity

Relation between Poisson's ratio, Modulus of Elasticity and Modulus of Rigidity

Deformation occurs in axial and transverse directions when an axial load is applied to a slender bar. This deformation impacts the cubic element within the bar, transforming it into either a rectangular parallelepiped or a rhombus, contingent on its orientation. This transformation process induces shearing strain. Axial loading elicits both shearing and normal strains. Applying an axial load instigates equal normal and shearing stresses on elements oriented at a 45° angle to the load axis.

Arteries and Arterioles

Arteries and Arterioles

Arteries, the vasculature responsible for transporting blood from the heart, possess robust walls capable of enduring the elevated pressures exerted by the heartbeat. Arteries near the heart are especially thick-walled and enriched with elastic fibers across their three tunics, classifying them as elastic or conducting arteries. These arteries, usually with a diameter exceeding 10 mm, are characterized by their ability to dilate in response to the blood pumped from the heart's ventricles and...

General Case of Eccentric Axial Loading

General Case of Eccentric Axial Loading

Unsymmetrical bending occurs when the bending moment applied to a structural member does not align with its principal axis. This misalignment leads to complex stress distributions and deflection patterns that differ from symmetrical bending, which are essential for designing structures to withstand different loading conditions.
Consider a member subjected to equal and opposite forces that are applied along a line that does not coincide with the member's neutral axis. In unsymmetrical bending,...

Unsymmetric Bending - Angle of Neutral Axis

Unsymmetric Bending - Angle of Neutral Axis

Unsymmetrical bending occurs when a structural member is subjected to bending moments in a plane that does not align with the member's principal axes. This scenario typically arises in beams and other structural components when loads are applied at non-ideal angles, introducing complexities in stress analysis.
When a bending moment is applied at an angle θ concerning the vertical axis of a symmetrical member, it can be resolved into components along the member's principal centroidal axes. The...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Arterial Growth and Remodeling in Layered and Toroidal Geometries Using Constrained Mixture Theory.

International journal for numerical methods in biomedical engineering·2026

Same author

Controlled intramural fluid injection to quantify propensity to thoracic aortic dissection.

bioRxiv : the preprint server for biology·2026

Same author

Transcriptional regulation of postnatal aortic development.

Cells & development·2024

Same author

Central Artery Hemodynamics in Angiotensin II-Induced Hypertension and Effects of Anesthesia.

Annals of biomedical engineering·2024

Same author

New computational approach to shunt design in congenital heart palliation.

Journal of biomechanics·2023

Same author

Ex vivo biomechanical characterization of umbilical vessels: Possible shunts in congenital heart palliation.

Journal of biomechanics·2023

Search research articles

Related Experiment Video

Updated: Jun 25, 2026

Biaxial Mechanical Characterizations of Atrioventricular Heart Valves

Biaxial Mechanical Characterizations of Atrioventricular Heart Valves

Published on: April 9, 2019

Normal basilar artery structure and biaxial mechanical behaviour.

B K Wicker¹, H P Hutchens, Q Wu

¹Department of Biomedical Engineering, Texas A&M University, College Station, TX 77843-3120, USA.

Computer Methods in Biomechanics and Biomedical Engineering

|February 21, 2009

Summary

Understanding cerebral artery mechanics is crucial for treating vasospasm after aneurysm rupture. This study models normal basilar artery structure and mechanics, providing a foundation for future research into vasospasm mechanisms.

More Related Videos

A Low Mortality Rat Model to Assess Delayed Cerebral Vasospasm After Experimental Subarachnoid Hemorrhage

A Low Mortality Rat Model to Assess Delayed Cerebral Vasospasm After Experimental Subarachnoid Hemorrhage

Published on: January 17, 2013

Biaxial Basal Tone and Passive Testing of the Murine Reproductive System Using a Pressure Myograph

Biaxial Basal Tone and Passive Testing of the Murine Reproductive System Using a Pressure Myograph

Published on: August 13, 2019

Related Experiment Videos

Last Updated: Jun 25, 2026

Biaxial Mechanical Characterizations of Atrioventricular Heart Valves

Biaxial Mechanical Characterizations of Atrioventricular Heart Valves

Published on: April 9, 2019

A Low Mortality Rat Model to Assess Delayed Cerebral Vasospasm After Experimental Subarachnoid Hemorrhage

A Low Mortality Rat Model to Assess Delayed Cerebral Vasospasm After Experimental Subarachnoid Hemorrhage

Published on: January 17, 2013

Biaxial Basal Tone and Passive Testing of the Murine Reproductive System Using a Pressure Myograph

Biaxial Basal Tone and Passive Testing of the Murine Reproductive System Using a Pressure Myograph

Published on: August 13, 2019

Area of Science:

Biomedical Engineering
Vascular Biology
Biomechanics

Background:

Cerebral vasospasm following ruptured intracranial aneurysms is a severe complication with unclear mechanisms and limited treatment options.
Understanding the mechanical properties and structure of healthy cerebral arteries is essential for elucidating vasospasm pathogenesis.

Purpose of the Study:

To investigate the structure and mechanical behavior of normal rabbit basilar arteries.
To develop a constitutive model for predicting arterial mechanical responses based on collagen fiber distribution.

Main Methods:

Mechanical testing of basilar artery segments under biaxial loading with and without active tone.
Intravital nonlinear optical microscopy to quantify transmural collagen fibril orientations.
Fitting passive mechanical data to a four-fiber family stress-stretch constitutive model.

Main Results:

The developed constitutive model accurately predicted the overall mechanical behavior of the basilar arteries.
The model successfully correlated mechanical data with mean collagen fiber distributions across the arterial wall.

Conclusions:

The constitutive model provides a promising tool for analyzing the biochemomechanics of cerebral vasospasm.
Future research should focus on mathematical models incorporating growth and remodeling of collagen to understand vasospasm mechanisms.