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Related Experiment Video

Updated: May 26, 2026

Quantitative Micro-CT Analysis of Aortopathy in a Mouse Model of β-aminopropionitrile-induced Aortic Aneurysm and Dissection
06:46

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Published on: July 16, 2018

Controlled intramural fluid injection to quantify propensity to thoracic aortic dissection.

C Cavinato1,2, B Pierrat3, E Ban2

  • 1LMGC, Univ. Montpellier, CNRS, Montpellier, France.

Biorxiv : the Preprint Server for Biology
|May 25, 2026
PubMed
Summary

This study reveals how fluid injection and mechanical stress cause aortic dissection. Increased stretch and injection rates worsen dissection, highlighting hydraulic fracture mechanics in the aortic wall.

Keywords:
aortic dissection mechanicsbiaxial mechanical testhistologymedial delaminationsynchrotron microtomography

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Last Updated: May 26, 2026

Quantitative Micro-CT Analysis of Aortopathy in a Mouse Model of β-aminopropionitrile-induced Aortic Aneurysm and Dissection
06:46

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Published on: July 16, 2018

An Approach to Point-Of-Care Ultrasound Evaluation of the Abdominal Aorta
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An Approach to Point-Of-Care Ultrasound Evaluation of the Abdominal Aorta

Published on: September 8, 2023

Area of Science:

  • Biomedical Engineering
  • Cardiovascular Biomechanics
  • Tissue Mechanics

Background:

  • Aortic dissection involves medial lamellar delamination and blood permeation.
  • Understanding the interaction between biaxial loading and fluid mechanics in dissection is crucial.

Purpose of the Study:

  • To investigate how axial stretch, injection rate, and needle gauge influence the initiation and propagation of intramural delamination.
  • To quantify the biomechanical conditions driving aortic dissection.

Main Methods:

  • Controlled distension-extension testing of porcine descending thoracic aortas.
  • Forced intramural fluid injection with varying parameters (stretch, rate, needle gauge).
  • Synchrotron imaging for microstructural analysis.

Main Results:

  • Nonlinear pressure-volume curves indicated progressive micro-delamination.
  • Increased axial stretch elevated injection pressure and promoted axial propagation.
  • Higher injection rates caused larger dissected areas; smaller needles increased upstream pressure.
  • Synchrotron imaging showed fluid permeation, swelling, and cavity formation.

Conclusions:

  • Aortic dissection can be modeled as hydraulic fracture in a poroelastic tissue.
  • The process is governed by fluid pressurization, wall loading, and interlamellar strength.
  • Findings offer quantitative insights into dissection biomechanics.