Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Combination of 3D and 2D Small and Wide Angle X-Ray Scattering Imaging Reveals Diminished Bone Quality in the Superior Human Femoral Neck Cortex.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Growth arrest of thoracic aortic aneurysms in aging Marfan mice.

American journal of physiology. Heart and circulatory physiology·2026
Same author

Controlled intramural fluid injection to quantify propensity to thoracic aortic dissection.

bioRxiv : the preprint server for biology·2026
Same author

Proximal Pulmonary Artery Stiffening as a Biomarker of Cardiopulmonary Aging.

Aging cell·2026
Same author

Community challenge towards consensus on characterization of biological tissue: C<sup>4</sup>Bio's first findings.

Journal of biomechanics·2025
Same author

Monolithic X-ray achromat.

Optics express·2025

Related Experiment Video

Updated: Jun 30, 2026

Quantitative Micro-CT Analysis of Aortopathy in a Mouse Model of &#946;-aminopropionitrile-induced Aortic Aneurysm and Dissection
06:46

Quantitative Micro-CT Analysis of Aortopathy in a Mouse Model of β-aminopropionitrile-induced Aortic Aneurysm and Dissection

Published on: July 16, 2018

Controlled intramural fluid injection to quantify propensity to thoracic aortic dissection.

Cristina Cavinato1,2, Baptiste Pierrat3, Ehsan Ban2

  • 1LMGC, Univ. Montpellier, CNRS, Montpellier, France.

Research Square
|June 29, 2026
PubMed
Summary

This study reveals how fluid pressure and mechanical forces cause aortic dissection by fracturing the aortic wall. Understanding these biomechanical factors is crucial for preventing aortic dissection progression.

Keywords:
aortic dissection mechanicsbiaxial mechanical testhistologymedial delaminationsynchrotron microtomography

More Related Videos

An Approach to Point-Of-Care Ultrasound Evaluation of the Abdominal Aorta
07:12

An Approach to Point-Of-Care Ultrasound Evaluation of the Abdominal Aorta

Published on: September 8, 2023

Related Experiment Videos

Last Updated: Jun 30, 2026

Quantitative Micro-CT Analysis of Aortopathy in a Mouse Model of &#946;-aminopropionitrile-induced Aortic Aneurysm and Dissection
06:46

Quantitative Micro-CT Analysis of Aortopathy in a Mouse Model of β-aminopropionitrile-induced Aortic Aneurysm and Dissection

Published on: July 16, 2018

An Approach to Point-Of-Care Ultrasound Evaluation of the Abdominal Aorta
07:12

An Approach to Point-Of-Care Ultrasound Evaluation of the Abdominal Aorta

Published on: September 8, 2023

Area of Science:

  • Biomedical Engineering
  • Cardiovascular Research
  • Materials Science

Background:

  • Aortic dissection involves medial lamellar delamination and blood permeation within the aortic media.
  • The interplay between biaxial loading and fluid mechanics in driving dissection is not fully understood.

Purpose of the Study:

  • To investigate how axial stretch, injection rate, and needle gauge influence intramural delamination propagation in porcine aortas.
  • To elucidate the biomechanical mechanisms underlying aortic dissection initiation and progression.

Main Methods:

  • Controlled distension-extension testing of porcine descending thoracic aortas.
  • Forced intramural fluid injection to simulate dissection conditions.
  • Synchrotron imaging to visualize fluid permeation and delamination cavity formation.

Main Results:

  • Nonlinear pressure-volume curves indicated progressive micro-delamination events.
  • Increased axial stretch elevated injection pressure and promoted axial delamination propagation.
  • Higher injection rates and smaller needle gauges led to larger dissected areas and higher pressures, respectively.
  • Synchrotron imaging showed the transition from permeation to a fluid-filled delamination cavity.

Conclusions:

  • Pressurized fluid within the aortic media acts as a hydraulic fracture process.
  • Aortic dissection is governed by fluid pressurization, wall loading, and interlamellar strength.
  • Findings offer insights into biomechanical conditions contributing to aortic dissection.