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Related Concept Videos

Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration01:25

Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration

Hemoperfusion and hemofiltration are critical techniques in medical treatments to eliminate accumulated drugs, metabolites, and electrolytes from the bloodstream. These methods are particularly vital in cases of accidental poisoning and drug overdose.Hemoperfusion involves passing blood through an adsorbent material to remove unwanted substances. The main adsorbents used in hemoperfusion include activated charcoal and Amberlite resins. Activated charcoal can adsorb both polar and nonpolar...
Hemodialysis II: Procedure and Complications01:24

Hemodialysis II: Procedure and Complications

DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
Hemodialysis I: Introduction01:25

Hemodialysis I: Introduction

Hemodialysis (HD) is a medical treatment that artificially removes waste products, excess fluids, and toxins from the blood when the kidneys are no longer able to perform these functions effectively. In this process, blood is filtered through a semipermeable membrane, allowing for the selective removal of waste while preserving necessary components like blood cells and proteins. Hemodialysis is typically performed in patients with end-stage renal disease (ESRD) or severe kidney...
Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy01:26

Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy (CRRT) is an essential intervention for patients experiencing severe kidney dysfunction. This therapy offers a continuous mechanism for removing fluids and toxins from the bloodstream, leveraging the patient’s blood pressure to facilitate filtration through a specialized filter. This method contrasts with intermittent dialysis, providing a gentler and more consistent removal of waste products and excess fluid, which is particularly beneficial in critically...
Continuous Renal Replacement Therapy01:30

Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy, also known as CRRT, is a procedural treatment for acute kidney injury (AKI) that gradually removes uremic toxins and fluids while maintaining acid-base balance and stabilizing electrolytes. It is particularly useful for hemodynamically unstable patients. Unlike intermittent hemodialysis, which is faster, CRRT provides a gentler approach over 24 hours, closely mimicking the function of natural kidneys. However, CRRT is not ideal for patients with...
Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis01:30

Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis

Patients with end-stage renal disease (ESRD) or those experiencing drug overdose often require extracorporeal methods to eliminate accumulated drugs and metabolites. Hemoperfusion, hemofiltration, and dialysis are the primary techniques to rapidly remove harmful substances without disrupting the patient's fluid and electrolyte balance. For those with compromised renal function, dosage adjustments of concurrent medications may be necessary during extracorporeal drug removal.Dialysis is a process...

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Related Experiment Video

Updated: Jun 25, 2026

A Modified EPA Method 1623 that Uses Tangential Flow Hollow-fiber Ultrafiltration and Heat Dissociation Steps to Detect Waterborne Cryptosporidium and Giardia spp.
12:11

A Modified EPA Method 1623 that Uses Tangential Flow Hollow-fiber Ultrafiltration and Heat Dissociation Steps to Detect Waterborne Cryptosporidium and Giardia spp.

Published on: July 9, 2012

[High-volume hemofiltrations].

P Honore, O Joannes-Boyau, W Boer

    Anesteziologiia I Reanimatologiia
    |February 21, 2009
    PubMed
    Summary
    This summary is machine-generated.

    High-volume hemofiltration (HVHF) at 35 ml/kg/hr significantly improves survival in acute renal failure (ARF) patients. This evidence-based approach requires careful implementation in intensive care settings.

    Related Experiment Videos

    Last Updated: Jun 25, 2026

    A Modified EPA Method 1623 that Uses Tangential Flow Hollow-fiber Ultrafiltration and Heat Dissociation Steps to Detect Waterborne Cryptosporidium and Giardia spp.
    12:11

    A Modified EPA Method 1623 that Uses Tangential Flow Hollow-fiber Ultrafiltration and Heat Dissociation Steps to Detect Waterborne Cryptosporidium and Giardia spp.

    Published on: July 9, 2012

    Area of Science:

    • Nephrology
    • Critical Care Medicine
    • Renal Replacement Therapy

    Context:

    • Evolving standards in hemofiltration (HF) from low ultrafiltration (UF) rates to high-volume approaches.
    • Emergence of high-volume hemofiltration (HVHF) with continuous and intermittent techniques.
    • Growing emphasis on evidence-based medicine in intensive care unit (ICU) protocols.

    Purpose:

    • To review the evolution and application of high-volume hemofiltration (HVHF) in acute renal failure (ARF).
    • To highlight the impact of increased ultrafiltration rates on patient survival.
    • To discuss the challenges and requirements for implementing HVHF in routine clinical practice.

    Summary:

    • Early hemofiltration used low ultrafiltration (UF) rates (<2 L/hr).
    • Studies demonstrated that increasing UF rates to 35 ml/kg/hr in acute renal failure (ARF) improves outcomes.
    • High-volume hemofiltration (HVHF) encompasses continuous (50-70 ml/kg/hr) and intermittent (100-120 ml/kg/hr) methods, with evidence suggesting a 20% survival increase in critically ill ARF patients at 35 ml/kg/hr.

    Impact:

    • Evidence supports higher doses of continuous veno-venous hemofiltration (CVVHF) at 35 ml/kg/hr, potentially increasing survival by 20% in critically ill ARF patients.
    • These findings may lead to Stage A recommendations for CVVHF use in ICUs.
    • Practical implementation faces challenges related to vascular access, blood flow, dilution procedures, membranes, fluids, and potential need for concomitant dialysis, requiring collaborative efforts between physicians and nurses.