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Nasopharyngeal Carcinoma Database.

K C Pua1, A S B Khoo, Y Y Yap

  • 1Department of Otorhinolaryngology, Hospital Pulau Pinang, Jalan Residensi, 10990 Penang, Malaysia.

The Medical Journal of Malaysia
|February 21, 2009
PubMed
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This study established a multi-institutional registry for nasopharyngeal carcinoma (NPC) in Malaysia. Early findings show most new NPC cases present with neck lumps and advanced stage III/IV disease.

Area of Science:

  • Oncology
  • Epidemiology
  • Clinical Research

Background:

  • Nasopharyngeal carcinoma (NPC) is prevalent in Asia.
  • Data on NPC presentation and staging in Malaysia is limited.
  • A systematic approach to data and sample collection is needed.

Purpose of the Study:

  • To establish a multi-institutional prospective study for nasopharyngeal carcinoma in Malaysia.
  • To systematically collect clinical data and biological samples (blood, tumor tissue).
  • To analyze early results regarding patient demographics, symptoms, and disease stage.

Main Methods:

  • Prospective, multi-institutional study design.
  • Inclusion of 484 confirmed nasopharyngeal carcinoma cases from six Malaysian centers.
  • Data collection from July 2007 to February 2008, categorizing cases into newly diagnosed, recurrent, and remission.

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Main Results:

  • A total of 484 nasopharyngeal carcinoma cases were registered.
  • Among 225 newly diagnosed cases, neck lumps were the most common symptom (42%).
  • Ophthalmo-neurologic symptoms presented in 11% of new cases, with 75% diagnosed at advanced stages (III/IV).

Conclusions:

  • The study successfully established a prospective NPC registry in Malaysia.
  • Early data highlights common presenting symptoms and advanced disease at diagnosis.
  • This infrastructure will facilitate further research into nasopharyngeal carcinoma.