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Updated: Jun 25, 2026
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Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
Published on: January 7, 2019
TT viruses: oncogenic or tumor-suppressive properties?
H zur Hausen1, E M de Villiers
1Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280,69120 Heidelberg, Germany. zurhausen@dkfz-heidelberg.de
Current Topics in Microbiology and Immunology
|February 24, 2009
Summary
Torque teno (TT) virus is found more often in cancer biopsies. Evidence suggests TT virus may indirectly cause cancer by affecting T cell immunity, rather than having direct oncolytic functions.
Area of Science:
- Virology
- Immunology
- Oncology
Background:
- Torque teno (TT) viruses are ubiquitous human viruses.
- Increased prevalence of TT virus DNA detected in malignant tissues compared to healthy controls.
Purpose of the Study:
- To evaluate the potential role of TT virus in human carcinogenesis.
- To investigate the potential oncolytic functions of TT virus infections.
Main Methods:
- Review of experimental evidence regarding TT virus and cancer.
- Analysis of potential mechanisms of viral involvement in tumorigenesis.
Main Results:
- TT virus infection may act as an indirect carcinogen by modulating T cell immune responses.
- Direct oncolytic functions of TT virus are considered less likely.
Conclusions:
- TT virus's role in cancer may be linked to immune modulation rather than direct cell killing.
- Further research is needed to elucidate the precise mechanisms of TT virus involvement in cancer development.
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