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Cephalometric changes produced by locally applied anabolic steroid in Wistar rats
Helena Cristina Francisco Pereira da Silva1, Rodrigo Cecanho
1College and Post Graduate Center of Dentistry, São Leopoldo Mandic, Campinas, Brazil. helenacfps@uol.com.br
Archives of Oral Biology
|February 24, 2009
Summary
Local anabolic steroid injections in rat masseter muscles altered craniofacial growth. This study investigated nandrolone decanoate
Area of Science:
- Craniofacial biology
- Muscle physiology
- Pharmacology
Background:
- Neuromuscular activity significantly influences facial skeletal development.
- Systemic anabolic steroids promote craniofacial growth and masticatory muscle activity.
- Investigating local application minimizes systemic side effects.
Purpose of the Study:
- To evaluate craniofacial changes from local nandrolone decanoate in rat masseter muscles.
- To assess potential alterations in facial skeletal morphogenesis.
- To determine effects with minimal systemic drug exposure.
Main Methods:
- Forty-three Wistar rats (3 weeks old) received bilateral masseter injections.
- Experimental group: nandrolone decanoate (NAN). Control group: sterile oil (CON).
- Cephalometric analysis and statistical tests (Tukey, Wilcoxon) were employed.
Main Results:
- Local nandrolone induced horizontalized facial growth (reduced FMA angle).
- Increased posterior and decreased anterior facial height observed.
- Gonial angle reduced, mandibular height increased, with no systemic effects.
Conclusions:
- Local nandrolone decanoate injection in the masseter muscle alters rat craniofacial growth direction.
- Morphological changes in the craniofacial complex were confirmed.
- Local application demonstrated efficacy in modifying growth patterns.
