Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Distribution of Molecular Speeds01:27

Distribution of Molecular Speeds

The motion of molecules in a gas is random in magnitude and direction for individual molecules, but a gas of many molecules has a predictable distribution of molecular speeds. This predictable distribution of molecular speeds is known as the Maxwell-Boltzmann distribution. The distribution of molecular speeds in liquids is comparable to that of gases but not identical and can help to understand the phenomenon of the boiling and vapor pressure of a liquid. Consider that a molecule requires a...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lattice Stiffening and Delayed Fluorescence in Columnar Liquid-Crystalline Glasses.

ChemPlusChem·2026
Same author

Advances in Peptide-Based Cancer Vaccines: Materials, Targeting, and Delivery Strategies.

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology·2025
Same author

An Integrated Method to Evaluate the Treatment Efficacy and Immunogenicity of B-Cell Acute Lymphoblastic Leukemia Therapeutic Enzyme Formulations.

Small methods·2025
Same author

Perfluorohexane Emulsions Induce Macrophage-Stimulating Effects through iNOS Expression.

ACS applied bio materials·2025
Same author

Targeted STING Activation Using Modified Ultrasound-Responsive Microbubbles Enhances Immune Checkpoint Blockade Against Melanoma.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2025
Same author

Hierarchical chirality observed from chiral supramolecular assembling of racemic and enantiopure helicene derivatives on silica nanohelix surfaces.

Nanoscale·2025

Related Experiment Video

Updated: Jun 25, 2026

Cargo Loading onto Kinesin Powered Molecular Shuttles
09:00

Cargo Loading onto Kinesin Powered Molecular Shuttles

Published on: November 3, 2010

A fast-moving copper-based molecular shuttle: synthesis and dynamic properties.

Fabien Durola1, Jacques Lux, Jean-Pierre Sauvage

  • 1Institut Le Bel, Université Louis Pasteur, 4 Rue Blaise Pascal, 67070 Strasbourg, France.

Chemistry (Weinheim an Der Bergstrasse, Germany)
|February 24, 2009
PubMed
Summary

Researchers synthesized a novel copper-based molecular shuttle using a nonhindering macrocycle, enabling faster ring motion. This design significantly accelerates the translation speeds in molecular machines.

More Related Videos

Assembling Molecular Shuttles Powered by Reversibly Attached Kinesins
08:04

Assembling Molecular Shuttles Powered by Reversibly Attached Kinesins

Published on: January 26, 2019

Millifluidics for Chemical Synthesis and Time-resolved Mechanistic Studies
12:55

Millifluidics for Chemical Synthesis and Time-resolved Mechanistic Studies

Published on: November 27, 2013

Related Experiment Videos

Last Updated: Jun 25, 2026

Cargo Loading onto Kinesin Powered Molecular Shuttles
09:00

Cargo Loading onto Kinesin Powered Molecular Shuttles

Published on: November 3, 2010

Assembling Molecular Shuttles Powered by Reversibly Attached Kinesins
08:04

Assembling Molecular Shuttles Powered by Reversibly Attached Kinesins

Published on: January 26, 2019

Millifluidics for Chemical Synthesis and Time-resolved Mechanistic Studies
12:55

Millifluidics for Chemical Synthesis and Time-resolved Mechanistic Studies

Published on: November 27, 2013

Area of Science:

  • Supramolecular Chemistry
  • Materials Science
  • Nanotechnology

Background:

  • Molecular machines require efficient components for controlled motion.
  • Rotaxanes are a class of mechanically interlocked molecules with potential applications in molecular devices.
  • Ligand design critically influences the dynamics and function of metallo-supramolecular systems.

Purpose of the Study:

  • To synthesize and characterize a new copper-based two-station [2]rotaxane molecular shuttle.
  • To investigate the effect of a sterically nonhindering endocyclic ligand (dpbiiq) on the dynamics of ring translation compared to a sterically hindering ligand (dpp).
  • To demonstrate the potential of optimized ligand design for enhancing the speed of molecular machine components.

Main Methods:

  • Multi-step synthesis of [2]rotaxane compounds.
  • Utilizing a copper-chelating fragment with either a sterically nonhindering dpbiiq macrocycle or a sterically hindering dpp macrocycle.
  • Kinetic studies to measure the translation rates of the macrocycle along the threaded axle for both copper(I) and copper(II) states.
  • Spectroscopic analysis for characterization of the synthesized rotaxanes.

Main Results:

  • Successfully synthesized a two-station [2]rotaxane featuring a copper-coordinating macrocycle with a sterically nonhindering endocyclic ligand (dpbiiq).
  • The dpbiiq-based shuttle exhibited significantly faster ring translation (orders of magnitude) compared to a similar shuttle with a sterically hindering dpp ligand.
  • The translation motion for the copper(I) state was rapid for both systems, while the copper(II) state showed a dramatic difference, with the dpbiiq system being significantly faster (<1 second vs. hours).

Conclusions:

  • The use of a sterically nonhindering, endocyclic ligand like dpbiiq is crucial for achieving fast translational motion in copper-based molecular shuttles.
  • Ligand design offers a powerful strategy for controlling and optimizing the speed of molecular machines.
  • These findings pave the way for developing more efficient and responsive molecular devices.