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The candy smell test: a new test for retronasal olfactory performance
Bertold Renner1, Christian A Mueller, Juergen Dreier
1Institute of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen-Nuremberg, Erlangen, Germany. bertold.renner@pharmakologie.med.uni-erlangen.de
The Laryngoscope
|February 25, 2009
Summary
A new Candy Smell Test (CST) reliably screens olfactory function in children and adults. This easy, fast test is suitable for ages 7 and up, offering a valuable tool for diagnosing smell disorders.
Area of Science:
- Olfactory research
- Sensory science
- Clinical audiology
Background:
- Olfactory dysfunction affects quality of life and can indicate underlying neurological conditions.
- Existing olfactory tests may not be suitable for children or are time-consuming.
- A need exists for a reliable, user-friendly olfactory test for diverse age groups.
Purpose of the Study:
- To develop and validate the Candy Smell Test (CST) for assessing retronasal olfaction in children and adults.
- To determine the minimum age for reliable olfactory testing.
- To compare CST performance against the established "Sniffin' Sticks" test.
Main Methods:
- A randomized, three-way crossover study involving 353 healthy participants (230 children, 123 adults).
- The Candy Smell Test (CST) uses 23 flavored sorbitol candies in a forced-choice format.
- Comparison with the "Sniffin' Sticks" test in 124 patients with olfactory disorders.
Main Results:
- The CST demonstrated good test-retest reliability (r=0.75).
- CST scores strongly correlated with "Sniffin' Sticks" scores (r=0.84), with CST being easier to administer.
- The minimum age for valid testing was 7 years for both methods.
- The CST achieved 94% sensitivity and 83% specificity in detecting anosmia.
Conclusions:
- The Candy Smell Test (CST) is a reliable, fast, and easy-to-use tool for screening olfactory function.
- CST is suitable for children aged 7 years and older, as well as adults.
- This test aids in the diagnosis of smell impairment in clinical settings.
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The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
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