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Updated: Jun 25, 2026
Fluorescence detection methods for microfluidic droplet platforms
Published on: December 10, 2011
Detection and analysis of low-abundance cell-surface biomarkers using enzymatic amplification in microfluidic
Haakan N Joensson1, Michael L Samuels, Eric R Brouzes
1Department of Nano Biotechnology, Royal Institute of Technology, AlbaNova University Center, 10691 Stockholm, Sweden. hakan.jonsson@biotech.kth.se
Abstract:
Finding the few: Cell-surface proteins are useful disease biomarkers, but current high-throughput methods are limited to detecting cells expressing more than several hundred proteins. Enzymatic amplification in microfluidic droplets (see picture) is a high-throughput method for detection and analysis of cell-surface biomarkers expressed at very low levels on individual human cells. Droplet optical labels allow concurrent analysis of several samples.
