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Tooth loss and osteoporosis: the OSTEODENT Study
Kety Nicopoulou-Karayianni1, Panagiotis Tzoutzoukos, Anastasia Mitsea
1Dental School, University of Athens, Athens, Greece.
Journal of Clinical Periodontology
|February 25, 2009
Summary
Osteoporosis is significantly associated with tooth loss in women aged 45-70. Osteoporotic patients had fewer teeth, even after accounting for age and smoking factors.
Area of Science:
- Oral health
- Bone metabolism
- Geriatric medicine
Background:
- Osteoporosis is a systemic skeletal disease characterized by low bone mass and microarchitectural deterioration of bone tissue, leading to enhanced bone fragility and a consequent increase in fracture risk.
- Tooth loss is a common condition in aging populations, influenced by various factors including periodontal disease, caries, and systemic conditions.
Purpose of the Study:
- To investigate the association between osteoporotic status and the number of remaining teeth in women.
- To determine if this association persists after adjusting for potential confounding factors like age and smoking.
Main Methods:
- Cross-sectional study involving 665 women aged 45-70 years across four centers.
- Bone mineral density was measured at the total hip, femoral neck, and lumbar spine.
- Number of teeth was counted for 651 participants.
Main Results:
- Osteoporotic subjects had a mean of 3.3 fewer teeth compared to non-osteoporotic subjects.
- This association remained statistically significant after adjusting for age, smoking, and study center (p < 0.016).
- Mixture regression models identified distinct clusters of tooth loss, with osteoporosis consistently linked to fewer teeth (-1.1 to -1.8 teeth).
Conclusions:
- A significant association exists between osteoporosis and tooth loss in middle-aged and older women.
- This relationship is independent of age and smoking status, highlighting a potential link between bone health and oral health.
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