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Allergic Reactions

Allergic Reactions

Allergic Reactions: Anaphylaxis

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...

Drug Toxicity: Allergic Reactions

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...

Allergic Drug Reactions

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...

Hypersensitivities

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...

Cross-reactivity

Cross-reactivity

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Related Experiment Video

Updated: Jun 25, 2026

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

Published on: March 24, 2023

[Contact allergy in children].

¹Klinik für Dermatologie, Venerologie und Allergologie, UKSH, Campus Kiel, Kiel, Deutschland. jbrasch@dermatology.uni-kiel.de

Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete

|February 25, 2009

Summary

This summary is machine-generated.

Contact allergy in children is common, with nickel and fragrances being frequent culprits. Patch testing and avoiding allergens are key for managing allergic contact dermatitis in kids.

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A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

Published on: June 4, 2017

Area of Science:

Dermatology
Allergology
Pediatrics

Context:

Contact allergy prevalence in children is largely unknown.
Common allergens include nickel, fragrances, and preservatives in personal care products.
Persistent eczema or suspected allergy warrants patch testing.

Purpose:

To outline diagnostic and management strategies for contact allergy in children.
To highlight common allergens and effective treatments for allergic contact dermatitis.
To emphasize prophylactic measures for preventing childhood contact allergies.

Summary:

Patch testing in children uses similar preparations and techniques as in adults, focusing on historically suggested allergens.
Small Finn-Chambers applied for one day are recommended, with careful assessment of positive readings for clinical relevance.
Treatment principles mirror adult care, prioritizing topical corticosteroids and avoiding non-steroidal anti-inflammatory drugs due to sensitization risk.

Impact:

Informs pediatricians and allergists on diagnosing and managing contact allergies in children.
Provides guidance on selecting appropriate allergens and testing methods for pediatric patients.
Emphasizes the importance of allergen avoidance for preventing and treating allergic contact dermatitis in childhood.