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Updated: Jun 25, 2026

Spin Saturation Transfer Difference NMR (SSTD NMR): A New Tool to Obtain Kinetic Parameters of Chemical Exchange Processes
Published on: November 12, 2016
Theoretical study of spin-spin coupling across the hydrogen (O-H...N) bond in adenosine derivatives
Marek Doskocz1, Agnieszka Strupińska, Szczepan Roszak
1Department of Bioorganic Chemistry, Faculty of Chemistry Wroclaw University of Technology, Wybrzeze Wyspiańskiego 27, 50-370 Wroclaw, Poland. marek.doskocz@pwr.wroc.pl
Abstract:
The study of spin-spin coupling constants across hydrogen bond provides useful information about configuration of complexes. The interesting case of such interactions was observed as a coupling across an intramolecular hydrogen bond in 8-bromo-2',3'-O-isopropylideneadenosine between the -CH2OH (at 5'' proton) group and the nitrogen atom of adenine. In this paper we report theoretical investigations on the 4hJNH coupling across the H''-C-O-H...N hydrogen bond in adenosine derivatives in various solvent models.
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