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Updated: Jun 25, 2026
Detection and Isolation of Campylobacter spp. from Raw Meat
Published on: February 23, 2024
Antimicrobial resistance of Campylobacter: prevalence and trends in Japan
Abstract:
Campylobacter is one of the most frequently diagnosed bacterial causes of human gastroenteritis in Japan and throughout the world. Resistance to quinolones in Campylobacter jejuni and C. coli isolated from humans has emerged in many countries during the past 15 years because fluoroquinolones are the drug of choice for the treatment of suspected bacterial gastroenteritis. Food contaminated with Campylobacter is the usual source of human infection; therefore, the presence of antimicrobial resistance strains in the food chain has raised concerns that the treatment of human infections will be compromised. The use of antimicrobial agents for food animals and in veterinary medicine is suspected to be correlated with an increase in quinolone-resistant strains of Campylobacter in food animals, especially in poultry products. In contrast to macrolide resistance in C. jejuni and C. coli isolated from humans showing a stable low rate, resistant Campylobacter spp. to quinolones have emerged in Japan. The paper summarizes food-borne Campylobacter infection in Japan, and the prevalence and trends of antimicrobial resistance of Campylobacter from the authors' data and other Japanese papers which reported the antimicrobial resistance of Campylobacter.
Insights
Quinolone resistance in Campylobacter bacteria is a growing concern in Japan, impacting human gastroenteritis treatment. This study examines Campylobacter infections and antimicrobial resistance trends in Japan, particularly in poultry.
Area of Science:
- Foodborne bacterial infections
- Antimicrobial resistance
- Veterinary medicine and public health
Background:
- Campylobacter is a leading cause of bacterial gastroenteritis globally and in Japan.
- Fluoroquinolones are primary treatments for bacterial gastroenteritis, leading to emerging resistance in Campylobacter jejuni and C. coli.
- Antimicrobial use in food animals, especially poultry, is linked to increased quinolone-resistant Campylobacter strains in the food chain.
Purpose of the Study:
- To summarize food-borne Campylobacter infections in Japan.
- To analyze the prevalence and trends of antimicrobial resistance in Campylobacter.
- To investigate quinolone resistance in Campylobacter spp. in Japan.
Main Methods:
- Review of authors' data on Campylobacter isolates.
- Analysis of published Japanese research on Campylobacter antimicrobial resistance.
- Examination of trends in quinolone and macrolide resistance.
Main Results:
- Quinolone-resistant Campylobacter strains have emerged in Japan, unlike stable low rates of macrolide resistance.
- Concerns exist regarding the compromised treatment of human infections due to resistant strains in the food chain.
- Poultry products are a suspected reservoir for quinolone-resistant Campylobacter.
Conclusions:
- Emergence of quinolone resistance in Campylobacter in Japan poses a significant public health challenge.
- Continued surveillance of antimicrobial resistance in Campylobacter within the food chain is crucial.
- Understanding the link between veterinary antimicrobial use and resistance is vital for effective control strategies.
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