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The anticonvulsive effect of BCH 325 is age dependent
A Becker1, R Grimm, G Grecksch
1Institute of Pharmacology and Toxicology, Medical Academy, Magdeburg, Germany.
Peptides
|May 1, 1991
Abstract:
The two different experimental approaches which were applied to study the anticonvulsive effectiveness of BCH 325, a des-tyrosine derivative of bovine beta-casomorphin-(5), in immature (22-day-old) and mature (7-week-old) female rats revealed that the peptide was able to protect mature females from electrically induced seizures and that it had no effect on pentylenetetrazol-induced convulsions. As opposed to this, immature animals were protected against chemically induced seizures but no effect was found using electrically induced seizures.