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Procedures for In Vitro Cultivation of Treponema pallidum, the Syphilis Spirochete
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Procedures for In Vitro Cultivation of Treponema pallidum, the Syphilis Spirochete

Published on: January 24, 2025

Update on neurosyphilis.

Christina M Marra1

  • 1University of Washington School of Medicine, Harborview Medical Center, Box 359775, 325 Ninth Avenue, Seattle, WA 98104, USA. cmarra@u.washington.edu

Current Infectious Disease Reports
|February 26, 2009
PubMed
Summary
This summary is machine-generated.

Neurosyphilis, a central nervous system infection, can manifest early or late and requires prompt diagnosis and treatment. Early detection and management are crucial, especially in HIV-positive individuals.

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Metagenomic Next-Generation Sequencing of Cerebrospinal Fluid for the Detection of Central Nervous System Pathogens

Published on: April 17, 2026

Area of Science:

  • Neurology
  • Infectious Diseases
  • Ophthalmology

Background:

  • Neurosyphilis is a serious complication of syphilis affecting the central nervous system.
  • It can occur at any stage of syphilis, not just the late
  • tertiary
  • stage.
  • It is increasingly observed in patients co-infected with HIV.

Purpose of the Study:

  • To critically review recent literature on neurosyphilis.
  • To cover diagnosis, clinical findings, risk factors, and management strategies.

Main Methods:

  • Literature review of recent publications on neurosyphilis.
  • Focus on diagnosis, clinical presentations, risk factors, and treatment.

Main Results:

  • Neurosyphilis affects meninges, vasculature, and parenchyma depending on the stage.
  • Ocular and auditory manifestations are common in early neurosyphilis.
  • HIV co-infection is a significant risk factor and impacts presentation and management.

Conclusions:

  • Neurosyphilis requires timely diagnosis and treatment, mirroring management for ocular and auditory syphilis.
  • Understanding risk factors, particularly HIV co-infection, is vital for effective patient care.