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Related Experiment Video

Updated: Jun 25, 2026

Tension-Free Weight-Bearing Model of Steroid-Induced Osteonecrosis of Femoral Head in Rats
05:55

Tension-Free Weight-Bearing Model of Steroid-Induced Osteonecrosis of Femoral Head in Rats

Published on: September 27, 2024

Glucocorticoid-induced osteoporosis.

Stuart L Silverman1, Nancy E Lane

  • 1Cedars-Sinai/UCLA and OMC Clinical Research Center, 8641 Wilshire Boulevard, Beverly Hills, CA 90211, USA. stuarts@omcresearch.org

Current Osteoporosis Reports
|February 26, 2009
PubMed
Summary

Glucocorticoid medications can cause bone loss and fractures. Early treatment with bone-sparing agents like bisphosphonates and teriparatide effectively prevents and treats this condition, known as glucocorticoid-induced osteoporosis.

Area of Science:

  • Endocrinology and Bone Metabolism
  • Pharmacology and Therapeutics

Background:

  • Glucocorticoid medications are widely used but can negatively impact bone health.
  • This can lead to reduced bone strength and an increased risk of osteoporotic fractures.
  • Glucocorticoid-induced osteoporosis (GIO) is a significant clinical concern, particularly in older individuals or with prolonged high-dose use.

Purpose of the Study:

  • To review the current understanding of glucocorticoid-induced osteoporosis (GIO).
  • To summarize epidemiological data, pathophysiology, and clinical evidence for bone-active agents in GIO management.

Main Methods:

  • Review of existing literature, including randomized controlled trials.
  • Analysis of studies investigating the efficacy of bisphosphonates and teriparatide in GIO.

Related Experiment Videos

Last Updated: Jun 25, 2026

Tension-Free Weight-Bearing Model of Steroid-Induced Osteonecrosis of Femoral Head in Rats
05:55

Tension-Free Weight-Bearing Model of Steroid-Induced Osteonecrosis of Femoral Head in Rats

Published on: September 27, 2024

  • Synthesis of information on risk factors, bone metabolism alterations, and fracture prevention strategies.

    • Main Results:

    • Glucocorticoid use is a significant risk factor for osteoporosis and fractures.
    • Bone loss associated with glucocorticoids is rapid, necessitating early intervention.
    • Bisphosphonates and teriparatide have demonstrated effectiveness in preventing and treating GIO.

    Conclusions:

    • Bone-active agents are crucial for preventing and treating glucocorticoid-induced osteoporosis.
    • Early intervention with agents like bisphosphonates and teriparatide can mitigate bone loss and reduce fracture risk.
    • Continued research and clinical application of these agents are vital for managing GIO.