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Updated: Jun 25, 2026

Sample Preparation and Transfer Protocol for In-Vacuum Long-Wavelength Crystallography on Beamline I23 at Diamond Light Source
Published on: April 23, 2021
A new on-axis multimode spectrometer for the macromolecular crystallography beamlines of the Swiss Light Source
Robin L Owen1, Arwen R Pearson, Alke Meents
1Swiss Light Source, Paul Scherrer Institute, CH-5232 Villigen PSI, Switzerland.
Abstract:
X-ray crystallography at third-generation synchrotron sources permits tremendous insight into the three-dimensional structure of macromolecules. Additional information is, however, often required to aid the transition from structure to function. In situ spectroscopic methods such as UV-Vis absorption and (resonance) Raman can provide this, and can also provide a means of detecting X-ray-induced changes. Here, preliminary results are introduced from an on-axis UV-Vis absorption and Raman multimode spectrometer currently being integrated into the beamline environment at X10SA of the Swiss Light Source. The continuing development of the spectrometer is also outlined.
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