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Erythropoiesis and iron metabolism biorhythms in children with chronic pyelonephritis

E N Barkova1, K A Lebedeva, E P Ashikhmina

  • 1Department of Pathophysiology, Department of Childhood Diseases, Pediatric Faculty, Tyumen State Medical Academy, Russia. barkova@tgma.info

Bulletin of Experimental Biology and Medicine
|February 26, 2009
PubMed

Insights

Chronic pyelonephritis alters red blood cell production in girls, affecting iron levels and leading to anemia. The study reveals changes in erythron kinetic populations and biomarker concentrations.

Area of Science:

  • Pediatric Hematology
  • Renal Medicine
  • Biochemistry

Background:

  • Chronic pyelonephritis can impact hematological parameters.
  • Erythropoiesis, the process of red blood cell production, involves distinct kinetic populations.
  • Iron metabolism and oxidative stress markers like MDA are crucial in health and disease.

Purpose of the Study:

  • To investigate the circadian dynamics of ferritin, serum iron, and MDA in girls with and without chronic pyelonephritis.
  • To analyze the relationship between erythron kinetic populations and these biomarkers during different phases of pyelonephritis.

Main Methods:

  • Studied healthy girls and girls with chronic pyelonephritis (aged 7-9 years).
  • Monitored circadian rhythms of ferritin, serum iron, and malondialdehyde (MDA).
  • Assessed erythron kinetic populations (ineffective, normal, terminal) and glucose-6-phosphate dehydrogenase activity.

Main Results:

  • Pyelonephritis remission showed increased macrocyte production, reducing morning serum iron and leveling its circadian rhythm.
  • Active pyelonephritis correlated with decreased erythrocytes and hemoglobin, increased microcytes, and elevated evening ferritin and MDA.
  • These changes were linked to the stimulation of alternative erythron kinetic types.

Conclusions:

  • Chronic pyelonephritis significantly disrupts normal erythropoiesis and iron metabolism in a circadian-dependent manner.
  • Altered erythron kinetics and elevated MDA/ferritin indicate increased oxidative stress and ineffective red blood cell production during active disease.
  • Understanding these dynamics is crucial for managing hematological complications in pediatric pyelonephritis.

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