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Proofreading and DNA Repair Assay Using Single Nucleotide Extension and MALDI-TOF Mass Spectrometry Analysis
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Proofreading and DNA Repair Assay Using Single Nucleotide Extension and MALDI-TOF Mass Spectrometry Analysis

Published on: June 19, 2018

Detection of single-nucleotide mismatches using scanning electrochemical microscopy

Piotr Michal Diakowski1, Heinz-Bernhard Kraatz

  • 1Department of Chemistry, The University of Western Ontario, 1151 Richmond Street, London, Ontario, CanadaN6A 5B7.

Chemical Communications (Cambridge, England)
|February 26, 2009
PubMed

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A scanning electron microscope (SEM) is used to study the surface features of a sample by using an electron beam that scans the sample surface in a two-dimensional manner. Typically, areas between ~1 centimeter to 5 micrometers in width can be imaged. SEM can be used to image bacteria, viruses, tissues as well as larger samples like insects. Conventional SEM gives a magnification ranging from 20X to 30,000X and spatial resolution of 50 to 100 nanometers.
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