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Updated: Feb 7, 2026

A Mouse Distraction Osteogenesis Model
Published on: November 14, 2018
[3-dimensional position changes of periorbital structures after midface distraction osteogenesis]
Zhe-Yuan Yu1, Xiong-Zheng Mu, Jia-Yi Han
1Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, China.
Midface distraction osteogenesis in Crouzon syndrome patients significantly advances and lowers periorbital bone structures. Eyeballs show minimal sagittal changes, with slight medial and downward shifts after the procedure.
Area of Science:
- Craniofacial surgery
- Orthognathic surgery
- Pediatric plastic surgery
Background:
- Crouzon syndrome causes midface hypoplasia, impacting facial aesthetics and function.
- Midface distraction osteogenesis is a surgical technique to correct these deformities.
Purpose of the Study:
- To quantify 3-D positional changes of periorbital structures after midface distraction osteogenesis in Crouzon syndrome patients.
- To compare post-operative changes with normal controls.
Main Methods:
- Retrospective analysis of CT data from 8 Crouzon syndrome patients (average age 11.9 years) before and one year after Le Fort III osteotomy with midface distraction.
- 3-D image reconstruction and establishment of a coordinate system.
- Measurement and comparison of pre- and post-operative positions of key orbital landmarks (SOr, IOr, MOr, LOr, AO, PO, rectus muscle insertions).
Main Results:
- Significant anterior and inferior displacement of the inferior orbit point (IOr), median orbit point (MOr), and lateral orbit point (LOr).
- The anterior ocularis point (AO) showed reduced inter-orbital distance but no significant vertical or depth changes.
- Inferior Rectus muscle insertions moved anteriorly and inferiorly.
Conclusions:
- Le Fort III osteotomy with midface distraction effectively repositions medial, lateral, and inferior periorbital bone structures anteriorly and inferiorly in Crouzon syndrome.
- Eyeball position demonstrates limited sagittal changes, with minor medial and downward movements and slight anterior-upward rotations.
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