CuI-Catalyzed Dearomatization/Peroxidation/Cyclization Cascade of Pyrrole-Tethered Indoles
Xue Sheng1, Liu Yang1, Jia-Yi Han1
1Laboratory of Asymmetric Synthesis, College of Chemistry and Environmental Engineering, Chongqing University of Arts and Sciences, 319 Honghe Avenue, Yongchuan, Chongqing 402160, P. R. China.
Abstract:
A mild CuI-catalyzed dearomatization/peroxidation/cyclization cascade of pyrrole-tethered indoles has been reached, providing peroxide-incorporated indolizino[8,7-b]indole derivatives in acceptable to good yields (46-76%). Dehydrogenated peroxide can be obtained by the use of a FeCl3/TBHP (tBuOOH)/2,2,2-trifluoroethanol (TFE) system at 50 °C.
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