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Related Concept Videos

Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
Replicative Cell Senescence02:15

Replicative Cell Senescence

Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...
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Metastasis

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Epithelial-to-Mesenchymal Transition
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Loss of Tumor Suppressor Gene Functions01:12

Loss of Tumor Suppressor Gene Functions

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
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Related Experiment Video

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Experimental Metastasis and CTL Adoptive Transfer Immunotherapy Mouse Model
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Published on: November 26, 2010

Learning therapeutic lessons from metastasis suppressor proteins.

Steven Christopher Smith1, Dan Theodorescu

  • 1Department of Molecular Physiology and Biological Physics, University of Virginia Health System, Charlottesville, Virginia 22908, USA.

Nature Reviews. Cancer
|February 27, 2009
PubMed
Summary

Metastasis suppressor proteins control cancer spread. Strategies to restore their function, like gene therapy, are being explored for cancer treatment and are in clinical trials.

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Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Metastasis Research

Background:

  • Metastasis suppressor proteins are key regulators of the metastatic cascade.
  • Their loss contributes to cancer cell invasion, survival in circulation, and organ colonization.
  • Understanding these proteins offers insights into therapeutic strategies.

Purpose of the Study:

  • To review current strategies for restoring metastasis suppressor function.
  • To highlight potential therapeutic opportunities based on metastasis suppressor biology.

Main Methods:

  • Review of existing literature on metastasis suppressor proteins.
  • Analysis of novel therapeutic strategies including gene transfer, gene expression induction, and protein administration.
  • Examination of targeting downstream pathways affected by metastasis suppressor loss.

Main Results:

  • Multiple strategies are being investigated to restore metastasis suppressor activity.
  • These include gene transfer, enhancing suppressed gene expression, and administering gene products.
  • Targeting pathways downstream of metastasis suppressor loss is also a viable approach.

Conclusions:

  • Restoring metastasis suppressor function holds therapeutic potential for cancer.
  • Current strategies are under preclinical and clinical investigation.
  • Further research may lead to clinical applications for managing cancer metastasis.