[Relation between drug intolerance and immunologic disorders in patients with pulmonary tuberculosis]

Data are given on the examination of 128 tuberculosis patients and 30 apparently healthy subjects. The basic parameters of T-cell immunity in tuberculosis patients associated with drug intolerance have been studied. Side effects of chemopreparations arise significantly more often with the initially impaired immunity parameters. A sharp imbalance of basic immune-regulatory T-cell subpopulations was noted prior to the development of clinical manifestations of immunity. The traditionally used methods for relieving drug intolerance fail to normalize T-system parameters. Patients with tuberculin anergy were noted to have an increased tendency to adverse reactions. The findings obtained help in recording the basic mechanisms of drug intolerance formation and development of methods for its prevention and correction.