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Related Experiment Videos

Antigenic variation in Plasmodium falciparum.

B A Biggs1, L Goozé, K Wycherley

  • 1Immunoparasitology Unit, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.

Proceedings of the National Academy of Sciences of the United States of America
|October 15, 1991
PubMed
Summary

Antigenic variation allows malaria parasites (Plasmodium falciparum) to evade immune responses. This study demonstrates Plasmodium falciparum exhibits antigenic variation in erythrocyte surface antigens, specifically the P. falciparum erythrocyte membrane protein 1.

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Area of Science:

  • Malariology
  • Immunology
  • Molecular Parasitology

Background:

  • Antigenic variation is a key immune evasion strategy for many pathogens.
  • Plasmodium falciparum, the causative agent of malaria, has been suspected of employing antigenic variation.
  • Previous studies lacked definitive proof of antigenic variation in P. falciparum.

Purpose of the Study:

  • To investigate and demonstrate antigenic variation in Plasmodium falciparum.
  • To identify the specific parasite-encoded protein responsible for antigenic differences on infected erythrocytes.
  • To provide definitive evidence of immune evasion through antigenic variation in this malaria parasite.

Main Methods:

  • Utilized cloned parasite lines of Plasmodium falciparum.
  • Conducted serological and biochemical analyses to examine erythrocyte surface antigen expression.

Related Experiment Videos

  • Compared progeny of cloned parasites for antigenic distinctness and genetic identity.

    • Main Results:

    • A cloned P. falciparum line produced progeny with antigenically distinct erythrocyte surface antigens.
    • These progeny were otherwise genetically identical, indicating variation within the clone.
    • The observed antigenic differences were attributed to variations in the P. falciparum erythrocyte membrane protein 1.

    Conclusions:

    • Plasmodium falciparum exhibits antigenic variation in clonal populations.
    • Antigenic variation of the P. falciparum erythrocyte membrane protein 1 is responsible for altered surface antigenicity.
    • This phenomenon is a significant mechanism for immune evasion by P. falciparum.