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The impact of fiber supplementation on ADMA levels
1Digestive Disease Center, Medical University of South Carolina, Department of Family Medicine, 295 Calhoun Street, Charleston, SC 29425, USA. kingde@musc.edu
Background:
Asymmetric dimethylarginine (ADMA) is an emerging biomarker that has been associated with oxidative metabolism and increased cardiovascular risk. Little information is available regarding the effect of diet on ADMA.
Methods:
The authors studied 86 overweight/obese adults as part of a clinical trial of psyllium supplementation to determine whether 3 months of such supplementation would affect ADMA levels. Forty-one people in the intervention group received 14 g/day of psyllium in addition to their usual diet compared with 45 controls who followed their usual diet alone. The 2 groups were comparable at baseline in demographic characteristics and body mass index.
Results:
Baseline ADMA levels were elevated in this overweight/obese population compared with published reference values in healthy individuals (0.75 vs 0.50 micromol/L). The change in ADMA levels over 3 months was not different in the psyllium group compared with the control group (-.03 vs -.01 micromol/L, P=.73).
Conclusions:
These findings do not support a significant effect of psyllium fiber supplementation on ADMA.
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