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Desipramine enhances isolation-induced aggressive behavior in mice
1Section of Pharmacology, Toyama Medical and Pharmaceutical University, Japan.
Pharmacology, Biochemistry, and Behavior
|May 1, 1991
Summary
Long-term isolation increases aggressive behavior in mice. Desipramine, an antidepressant, amplifies this aggression, an effect modulated by alpha-2 noradrenergic receptors.
Area of Science:
- Neuroscience
- Pharmacology
- Behavioral Science
Background:
- Long-term isolation in mice is known to induce behavioral changes.
- Antidepressants like desipramine can affect neurotransmitter systems involved in mood and behavior.
Purpose of the Study:
- To investigate the effects of desipramine on aggression induced by long-term isolation in mice.
- To explore the role of noradrenergic receptors in mediating desipramine's effect on aggression.
Main Methods:
- Mice were subjected to 6-7 weeks of isolation to induce aggressive behavior.
- Desipramine and imipramine were administered at various doses (mg/kg, IP) to assess their impact on aggression.
- The effects of alpha-adrenergic antagonists (phentolamine, yohimbine, prazosin) and an alpha-2 agonist (clonidine) on desipramine-induced aggression were evaluated.
Main Results:
- Desipramine and imipramine dose-dependently increased aggressive behavior in isolated mice but not in group-housed mice.
- Phentolamine and yohimbine blocked the desipramine-induced increase in aggression, while prazosin did not.
- Clonidine significantly blocked the enhancement of aggressive behavior caused by desipramine in isolated mice.
Conclusions:
- Long-term isolation may alter the sensitivity of alpha-2 receptors within the noradrenergic system.
- Desipramine's enhancement of aggressive behavior in isolated mice is influenced by interactions with alpha-2 noradrenergic receptors.