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Related Concept Videos

The Thyroid Gland01:23

The Thyroid Gland

The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...

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Related Experiment Video

Updated: Jun 25, 2026

Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma
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Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma

Published on: September 15, 2023

Contralateral papillary thyroid cancer: does size matter?

Susan C Pitt1, Rebecca S Sippel, Herbert Chen

  • 1Section of Endocrine Surgery, Department of Surgery, University of Wisconsin, Madison, WI, USA. pitt@surgery.wisc.edu

American Journal of Surgery
|February 28, 2009
PubMed
Summary
This summary is machine-generated.

For small papillary thyroid cancers (<1 cm), tumor size does not predict contralateral disease. Multifocality is the key risk factor for contralateral papillary thyroid cancer (PTC) in these patients.

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Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma
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Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
03:55

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer

Published on: June 9, 2023

Area of Science:

  • Endocrinology
  • Oncology
  • Surgical Oncology

Background:

  • The optimal surgical management for small papillary thyroid cancer (<1 cm) remains debated.
  • Contralateral disease rates in these patients require further clarification.

Purpose of the Study:

  • To determine the incidence of contralateral papillary thyroid cancer (PTC) in patients with primary PTC <1 cm.
  • To identify factors predicting the presence of contralateral PTC in this patient group.

Main Methods:

  • Retrospective analysis of 228 patients with PTC undergoing total or completion thyroidectomy.
  • Evaluation of tumor size, histology, margin status, capsular invasion, extrathyroid extension, multifocality, and nodal status as predictive factors.

Main Results:

  • No significant difference in contralateral PTC rates between tumors >=1 cm (30%) and <1 cm (24%).
  • Multifocality was the sole significant predictor of contralateral PTC in tumors <1 cm (P=.02).
  • Tumors <0.5 cm showed a similar contralateral disease rate (27%).

Conclusions:

  • Primary tumor size is not associated with the risk of contralateral PTC.
  • Multifocality is a crucial risk factor for contralateral PTC in patients with small papillary thyroid cancer (<1 cm).