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Non-invasive Imaging and Analysis of Cerebral Ischemia in Living Rats Using Positron Emission Tomography with 18F-FDG

Non-invasive Imaging and Analysis of Cerebral Ischemia in Living Rats Using Positron Emission Tomography with ¹⁸F-FDG

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PET/SPECT imaging: from carotid vulnerability to brain viability.

Robbert Meerwaldt¹, Riemer H J A Slart, Gooitzen M van Dam

¹Department of Surgery, Isala Clinics, Zwolle, The Netherlands.

European Journal of Radiology

|February 28, 2009

Summary

Positron emission tomography (PET) and single photon emission computed tomography (SPECT) can identify vulnerable carotid plaques and assess brain viability in ischemic stroke patients. These functional imaging tools aid in selecting patients for timely intervention, improving treatment strategies.

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Last Updated: Jun 25, 2026

Non-invasive Imaging and Analysis of Cerebral Ischemia in Living Rats Using Positron Emission Tomography with 18F-FDG

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Integrated Photoacoustic, Ultrasound, and Angiographic Tomography (PAUSAT) for NonInvasive Whole-Brain Imaging of Ischemic Stroke

Integrated Photoacoustic, Ultrasound, and Angiographic Tomography (PAUSAT) for NonInvasive Whole-Brain Imaging of Ischemic Stroke

Published on: June 2, 2023

Area of Science:

Neurology
Radiology
Cardiovascular Medicine

Background:

Ischemic stroke management faces challenges with carotid plaque vulnerability, brain viability, and intervention timing.
The principle 'time is brain' emphasizes urgent interventions for ischemic stroke.
Functional imaging, including positron emission tomography (PET) and single photon emission computed tomography (SPECT), offers potential for improved patient selection and viability assessment.

Purpose of the Study:

To review the current applications of PET and SPECT in diagnosing ischemic stroke.
To explore the role of functional imaging in assessing carotid plaque vulnerability and brain viability.

Main Methods:

A literature search was conducted using PubMed.
Manual cross-referencing of identified articles was performed.

Main Results:

PET/SPECT can monitor treatments for systemic atheroma and identify high-risk patients for carotid surgery, irrespective of stenosis degree.
PET/SPECT quantifies the ischemic penumbra, aiding in the identification of patients who would benefit from prompt intervention.

Conclusions:

Functional imaging with PET/SPECT shows promise for risk assessment and treatment strategy evaluation in carotid plaque vulnerability and brain viability.
Further prospective clinical studies are required to validate the diagnostic accuracy of PET/SPECT.