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Published on: July 30, 2017
Bioactive metabolites produced by Chaetomium globosum, an endophytic fungus isolated from Ginkgo biloba
Jian-Chun Qin1, Ya-Mei Zhang, Jin-Ming Gao
1College of Science, Northwest A & F University, Yangling, Shaanxi 712100, China.
Abstract:
A novel cytotoxic chlorinated azaphilone derivative named chaetomugilin D (1), together with three known metabolites, chaetomugilin A (2), chaetoglobosins A (3) and C (4), has been isolated by a bioassay-guided fractionation from the EtOAc extract of the cultures of Chaetomium globosum, an endophytic fungus found in the leaves of Ginkgo biloba. Structure of 1 was established by analyses of spectroscopic methods, including 2D-NMR experiments (COSY, NOESY, HMQC, and HMBC). Compounds 1-4 displayed significant growth inhibitory activity against the brine shrimp (Artemia salina) and Mucor miehei.
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