Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neutron effects on the lens.

C Medvedovsky1, B V Worgul

  • 1Eye Radiation and Environmental Research Laboratory, Columbia University, New York, New York 10032.

Radiation Research
|October 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dosimetry for a study of low-dose radiation cataracts among Chernobyl clean-up workers.

Radiation research·2007
Same author

Cataracts among Chernobyl clean-up workers: implications regarding permissible eye exposures.

Radiation research·2007
Same author

Mice heterozygous for the ATM gene are more sensitive to both X-ray and heavy ion exposure than are wildtypes.

Advances in space research : the official journal of the Committee on Space Research (COSPAR)·2005
Same author

Use of subjective and nonsubjective methodologies to evaluate lens radiation damage in exposed populations--an overview.

Radiation and environmental biophysics·1996
Same author

Quantitative comparisons of continuous and pulsed low dose rate regimens in a model late-effect system.

International journal of radiation oncology, biology, physics·1996
Same author

Quantitative assessment of the cataractogenic potential of very low doses of neutrons.

Radiation research·1996

The human lens serves as a biological dosimeter for radiation effects. Cataract formation, a stochastic radiation effect, shows higher relative biological effectiveness (RBE) for neutrons compared to X-rays, with evidence of an inverse dose-rate effect.

Area of Science:

  • Radiobiology
  • Ophthalmology
  • Radiation Oncology

Background:

  • The human lens has historically served as a biological dosimeter for radiation effects.
  • Understanding neutron radiation effects on humans is crucial, particularly following the Hiroshima/Nagasaki experience.
  • Cataractogenesis offers insights into ocular radiopathy and fundamental radiation mechanisms.

Purpose of the Study:

  • To assess the merits of the lens for evaluating neutron effects in humans.
  • To review existing data on human lens radiation exposure and cataract development.
  • To discuss challenges in extrapolating findings from experimental animal models.

Main Methods:

  • Review of radiobiological principles and historical data on lens response to radiation.

Related Experiment Videos

  • Analysis of experimental animal data and findings related to photon (X and gamma rays) and neutron exposure.
  • Examination of human population data, including Western and USSR sources, for known radiation doses and cataract outcomes.

    • Main Results:

    • Cataract formation, previously considered nonstochastic, is increasingly understood as a stochastic effect, likely initiated by somatic mutations.
    • Relative biological effectiveness (RBE) values for neutron-induced cataracts are significantly higher than those for X-rays.
    • Evidence suggests an inverse dose-rate effect in the production of radiation-induced cataracts.

    Conclusions:

    • The lens is a valuable in vivo system for assessing radiation effects, particularly neutron exposure.
    • Somatic mutations in the lens appear to be the primary damage mechanism, supporting a stochastic model for cataractogenesis.
    • Further research is needed to refine dose estimations and extrapolation methods for human neutron radiation exposure.