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Related Experiment Video

Updated: Jun 25, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Published on: June 16, 2020

Work disability in systemic lupus erythematosus.

Ali M Al Dhanhani1, Monique A M Gignac, Jiandong Su

  • 1Toronto Western Hospital of the University Health Network, Toronto, Ontario, Canada.

Arthritis and Rheumatism
|February 28, 2009
PubMed
Summary
This summary is machine-generated.

Work disability is common in systemic lupus erythematosus (SLE), affecting 23% of patients. Factors like younger age, less education, comorbidities, and lupus disease activity increase this risk.

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Area of Science:

  • Rheumatology
  • Public Health
  • Occupational Medicine

Background:

  • Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with significant impact on patients' lives.
  • Work disability is a major concern for SLE patients, affecting their quality of life and economic stability.

Purpose of the Study:

  • To determine the prevalence and incidence of work disability in patients with SLE.
  • To identify risk factors associated with work disability in this population.

Main Methods:

  • Prospective study of 432 patients from an inception cohort.
  • Work disability assessed via self-report; data included sociodemographics, clinical lupus features (SLEDAI-2K, SLICC/ACR DI), health status (SF-36), comorbidity, and medication.
  • Statistical analyses included t-tests, chi-square tests, survival curves, and logistic regression.

Main Results:

  • Overall work disability prevalence was 23% (98/432 patients).
  • Within the first year, 7% of patients had a disability and 7% were on sick leave.
  • Multivariate analysis identified younger age at diagnosis, less education, fibromyalgia, hypertension, higher SLEDAI-2K, and lower SF-36 scores as risk factors.

Conclusions:

  • Work disability is a frequent outcome in SLE patients, with a cumulative prevalence of 23%.
  • Associated factors include comorbidities, physical/mental health limitations, and clinical lupus features.
  • These findings highlight the need for increased attention and research into managing work disability in SLE.