[Combined treatment of nephrolithiasis with canephron H]

Area of Science:

• Nephrology
• Urology
• Pharmacology

Background:

• Nephrolithiasis, or kidney stones, is a common condition associated with elevated urinary enzyme levels.
• Assessing urinary enzymes can provide insights into kidney damage and inflammation.
• Current treatments for nephrolithiasis include extracorporeal shock wave lithotripsy (ESWL) and pharmacotherapy.

Purpose of the Study:

• To evaluate the effect of Canephron H on urinary enzyme excretion in nephrolithiasis patients.
• To compare the efficacy of Canephron H alone, ESWL alone, and a combination therapy in managing kidney stones.
• To investigate the role of Canephron H in mitigating renal stress during ESWL treatment.

Main Methods:

• A clinical trial involving 35 nephrolithiasis patients aged 26-64 years.
• Patients were divided into three groups: Canephron H monotherapy, ESWL with standard therapy, and Canephron H combined with ESWL.
• Urinary enzyme levels (alkaline phosphatase, LDH, GGT, NAG, LAP) were measured at baseline and during the study period.

Main Results:

• All patient groups initially presented with high levels of urinary enzymes (enzymuria).
• Canephron H therapy alone or in combination with ESWL significantly reduced urinary enzyme levels.
• While ESWL caused a temporary increase in urinary enzymes, the rise was less pronounced in patients receiving Canephron H concurrently.

Conclusions:

• Canephron H demonstrates a significant role in reducing enzymuria associated with nephrolithiasis.
• The combination of Canephron H with ESWL appears to offer a beneficial therapeutic approach for kidney stone management.
• Canephron H can be considered as an adjunct therapy to standard treatments for nephrolithiasis, potentially improving patient outcomes.