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Updated: Jun 25, 2026

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Published on: October 11, 2022
Antitumour and antimalarial activity of artemisinin-acridine hybrids
Michael Jones1, Amy E Mercer, Paul A Stocks
1Department of Chemistry, University of Liverpool, Crown Street, Liverpool L69 7ZD, UK.
Abstract:
Artemisinin-acridine hybrids were prepared and evaluated for their in vitro activity against tumour cell lines and a chloroquine sensitive strain of Plasmodium falciparum. They showed a 2-4-fold increase in activity against HL60, MDA-MB-231 and MCF-7 cells in comparison with dihydroartemisinin (DHA) and moderate antimalarial activity. Strong evidence that the compounds induce apoptosis in HL60 cells was obtained by flow cytometry, which indicated accumulation of cells in the G1 phase of the cell cycle.
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