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Related Experiment Video

Updated: Jun 14, 2026

Quantitative Proteomics Using Reductive Dimethylation for Stable Isotope Labeling
11:53

Quantitative Proteomics Using Reductive Dimethylation for Stable Isotope Labeling

Published on: July 1, 2014

Improved CILAT reagents for quantitative proteomics.

Dexing Zeng1, Shuwei Li

  • 1Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute, 9600 Gudelsky Drive, MD 20850, USA.

Bioorganic & Medicinal Chemistry Letters
|March 3, 2009
PubMed
Summary
This summary is machine-generated.

New CILAT reagents enable high-throughput measurement of numerous protein samples. This offers a powerful tool for mass spectrometry-based quantitative proteomics.

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Last Updated: Jun 14, 2026

Quantitative Proteomics Using Reductive Dimethylation for Stable Isotope Labeling
11:53

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Published on: July 1, 2014

Selected Reaction Monitoring Mass Spectrometry for Absolute Protein Quantification
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Published on: August 17, 2015

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Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

Published on: November 15, 2017

Area of Science:

  • Biochemistry
  • Analytical Chemistry
  • Proteomics

Background:

  • Quantitative proteomics is crucial for understanding biological processes.
  • High-throughput assays are needed to analyze large numbers of protein samples efficiently.
  • Existing methods may have limitations in throughput and sample capacity.

Purpose of the Study:

  • To develop and validate improved CILAT reagents for enhanced protein sample analysis.
  • To establish a robust tool for high-throughput, mass spectrometry-based quantitative proteomics.

Main Methods:

  • Development of novel CILAT reagents.
  • Application of these reagents in high-throughput assays.
  • Mass spectrometry-based quantitative proteomics analysis.

Main Results:

  • The improved CILAT reagents allow for the measurement of an unprecedented number of protein samples.
  • The developed method provides a robust platform for quantitative proteomics.
  • High-throughput analysis capabilities were significantly enhanced.

Conclusions:

  • Improved CILAT reagents represent a significant advancement in quantitative proteomics.
  • These reagents provide a robust and high-throughput tool for large-scale proteomic studies.
  • The findings facilitate deeper insights into biological systems through comprehensive protein analysis.